DeBeers unchallenged

Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana.

Activity-based protein profiling is a powerful method to display enzyme activities in proteomes and provides crucial information on enzyme activity rather than protein or transcript abundance. We applied activity-based protein profiling using fluorophosphonate-based probes to display the activities of Ser hydrolases in the model plant Arabidopsis thaliana. Multidimensional protein identificatio...

Lest we forget: why the use of chemical weapons must not go unchallenged.

Unquoted, unchallenged, general practice research will be casting pearls before swine.

Research is themajor driving factor in further improving health care and should be directed at the clinical decisions that have the greatest impact on the health status of the population. Most people receive formal medical care in general practice, and GPs are in many countries the only physicians directly accessible to the public. Primary care is where research will contribute most to improve ...

Unchallenged good intentions: a qualitative study of the experiences of medical students on international health electives to developing countries

BACKGROUND Irish medical students have a long and proud history of embarking on international health electives (IHEs) to broaden their experience in the developing world. Although there are many opinions in the literature about IHEs, there is a dearth of empirical research that explores the experience and the value of these experiences to medical students. Most students who participate in these...

Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice

Sickle cell disease (SCD) is a genetic disorder that leads to red blood cell (RBC) sickling, hemolysis and the upregulation of adhesion molecules on sickle RBCs. Chronic hemolysis in SCD results in a hyper-inflammatory state characterized by activation of circulating leukocytes, platelets and endothelial cells even in the absence of a crisis. A crisis in SCD is often triggered by an inflammator...